A decreased risk at 6Р’В months was associated with an interaction among the same SNPs of SFTPB and SFTPD and the rs1136450 of SFTPA1. An increased risk at 12Р’В months was associated with one intragenic (rs1965708 and rs113645 of SFTPA2) interaction 4) in a three-SNP model, decreased and increased risks at 6 and 12Р’В months, respectively, were associated with an interaction among rs1130866 of SFTPB, rs721917 of SFTPD, and rs1059046 of SFTPA2. We found that 1) in the multivariate analysis, an increased risk at 6 and 12Р’В months was associated with rs1124_A and rs4715_A of SFTPC, respectively 2) in a single SNP model, increased and decreased risks of PRM at both timepoints were associated with rs1124 of SFTPC and rs721917 of SFTPD, respectively an increased risk at 6Р’В months was associated with rs1130866 of SFTPB and rs4715 of SFTPC, and increased and decreased risks at 12Р’В months were associated with rs17886395 of SFTPA2 and rs2243639 of SFTPD, respectively 3) in a two-SNP model, PRM susceptibility at both timepoints was associated with a number of intergenic interactions between SNPs of the studied SP genes. Logistic regression analysis and SNPРІР‚вЂњSNP interaction models were used. Of the 250 enrolled subjects, 155 and 127 were followed at 6 and 12Р’В months after an ARF episode, respectively. We studied associations of persistent respiratory morbidity (PRM) at 6 and 12Р’В months after acute respiratory failure (ARF) in previously healthy children with single-nucleotide polymorphisms (SNPs) of surfactant protein (SP) genes.

5Department of Obstetrics and Gynecology, Pennsylvania State University College of Medicine, Hershey, PA, United States.4Department of Pediatrics, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, United States.3Public Health Science, Pennsylvania State University College of Medicine, Hershey, PA, United States.2Center for Computational Biology, College of Biological Sciences and Technology, Beijing Forestry University, Beijing, China.1Center for Host Defense, Inflammation, and Lung Disease (CHILD) Research, Department of Pediatrics, Pennsylvania State University College of Medicine, Hershey, PA, United States.

Thomas 1, Ye Meixia 2, Debbie Spear 1, Chenqi Fu 3, Shouhao Zhou 3, Rongling Wu 3, Garrett Keim 4, Nadir Yehya 4 and Joanna Floros 1,5*

Dahmer 2002 full text